Life after death: are trypanosomatids programmed to die for the survival of their partners?

نویسندگان

  • Nicolas Fasel
  • Masina Slavica Masina
چکیده

In the year 1315, on the battle field of Morgarten, a Swiss hero named Winkelried, stabbed himself with lances he grabbed from the wall of armed Austrian soldiers. His sacrifice, was thus essential to open the way for the victory of the Swiss army. In his mind, there was a clear suicide plan under which action was taken towards a goal, that is, the survival of his colleagues. Such a suicide plan is found at the cellular level in metazoa, namely in their cell death program. Programmed cell death (PCD), is a suicidal pathway that has clear benefits for multicellular organisms, whereby, cells that are damaged, infected, or no longer required are eliminated. Considering the importance of PCD in metazoa, it is reasonable to ask if such a predetermined mechanism of behavior, or operations, exists in phylogenetically ancient, single cell organisms, such as, pathogenic trypanosomatids.

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عنوان ژورنال:
  • Kinetoplastid Biology and Disease

دوره 2  شماره 

صفحات  -

تاریخ انتشار 2003